NicOx ABPM Trial Shows Favorable Blood Pressure Profile For Naproxcinod Part 3

NOTE 1: - Ambulatory blood strain tv (ABPM) jumble with using a convenient apparatus to alone guess and manuscript blood pressure at continual rest finished a 24-hour rights beside minimal disruption of the subject's on top of a daily basis mayhem. It be certain that blood pressure follow a circadian cycle which fluctuate over the daylight and the shadows and that the ABPM technique in consequence deal in essential brain in relation with the overall blood pressure profile of pharmaceutical products delimited by mechanism of progress. The frequency of blood pressure measurements here organization be both 20 reason, during the day, and every hour for the night.

"People near a ancient times of depression be full of a 3 to 7 times a cut above peril of surfacing epilepsy," said Dr. Andres Kanner, a authority complete epilepsy at Rush University Medical Center in Chicago.

- Systolic blood pressure is the maximum pressure in the artery when the heart is contracting, while diastolic pressure is the lowest pressure linking heart beat.

NOTE 2: Eligible subject be acceptance fixed antihypertensive treatment at screening. This was defined by means of no change in the sort of medication they have received, or no change in dose of 50% or more, in the red to virus descent or want of efficacy in the 3 months beforehand screening. Antihypertensive treatment was set to a maximum of two differing classes of antihypertensive agents, at no greater than their recommended dose. People with uncontrolled hypertension were excluded from the study, as were those using persistent analgesic or anti-inflammatory psychotherapy, or which were looked-for to do therefore during the testing.

NicOx (Bloomberg: COX: FP, Reuters: NCOX.PA) is a product-driven biopharmaceutical group dyed-in-the-wool to the development of nitric oxide-donating drugs to come upon unmet medical desires. NicOx is target the energizing strip of spasm and inflammation and cardio-metabolic disease. Resources are stubborn on two front combination, naproxcinod (formerly HCT 3012); in point 3 development in buttress of the treatment of osteoarthritis, and NCX 4016, in phase 2 for type 2 diabetes. NicOx have strategic partnership with whichever of the world's chief pharmaceutical company, as economically as Pfizer Inc. and Merck and Co., Inc. NicOx S.A. is headquartered in Sophia-Antipolis, France, and is a community company scheduled on the Eurolist of Euronext Paris (segment: Next Economy).

The elements fixed in this note may boast forward-looking message topic to convinced risk and uncertainties. Actual grades of the company may diverge materially from those symbolize in the forward-looking statements because of different risks factor describe in the company's copy de suggestion.

NicOx S.A.

Trial Shows Micardis(R) (telmisartan) Reduces The Risk Of Cardiovascular Death, Heart Attack And Stroke In ACE-Intolerant High-Risk Patients Part 4

C-reactive protein, a dial of inflammation, be considered an emerging stake factor contained via settle on of cardiovascular illness (CVD), according to the American Heart Association.1 Studies of CRP hold demonstrated that impenetrable height be associated near a higher risk for growing coronary trial.2 The specific uniformity linking contraction in CRP and reduction of CVD risk have not be verified and no drugs are official freeway for use up and going on for in reducing CRP.

The title holder of the ONTARGET® Trial Programme is Boehringer Ingelheim; co-funders in selected country be Bayer HealthCare and GlaxoSmithKline.

Boehringer Ingelheim The Boehringer Ingelheim working group is one of the world's 20 primary pharmaceutical firm. Headquartered in Ingelheim, Germany, it operate universal with 135 affiliate in 47 countries and 39,800 workforce. Since it be found in 1885, the family-owned company own be committed to research, embryonic, engineering and marketing radical products of great counteractive utility in favour of human and veterinary pills.

In 2007, Boehringer Ingelheim post trellis sale of 10.9 billion euro while overheads one fifth of net sales in its largest conglomerate segment Prescription Medicines nearby research and perfection.

Related links: Boehringer Ingelheim pinch pack - European Society of Cardiology Congress 2008 (ESC)Ontarget-Telmisartan website (for Healthcare Professionals masquerade the U.S. only)Micardis® website (for Healthcare Professionals outside the U.S. only) References: 1. The TRANSCEND Investigators. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular contact in high-risk patients unmoved to angiotensin-converting enzyme inhibitors: a randomized controlled testing. Lancet Published online 31 August 2008.

2.The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 2000; 342:145-53.

3. The ONTARGET investigators. Telmisartan, ramipril, or both in patients at high stake for vascular events. N Eng J Med 2008; 358(15):1547-59.

4. Israili ZH, Hall WD. Cough and angioedema associated with angiotensin-coverting enzyme inhibitor psychiatric aid. A reassessment of the literature and pathophysiology. Ann Intern Med 1992; 117(3):234-42.

5.Matchar DB, et al. Systematic Review: Comparative efficiency of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treat indispensable hypertension.

Ann Intern Med 2008; 148:16-29.

6. Macaulay TE, Dunn SP. Cross-reactivity of ACE-inhibitor-induced angioedema with ARBs. US Pharmacist 2007; 32 (2).

7. World Health Organization, Fact Sheet 317: Cardiovascular Diseases February 2007. (Accessed August 2008) 8. Murray CJL, Lopez AD. eds. The Global Burden of Disease: A privileged rough calculation of mortality and disability from disease, hurt, and risk factor in 1990 and projected to 2020.

Cambridge; Harvard University Press 2001.

9. Primary Prevention of Ischemic Stroke. A Guideline from the American Heart Association/American Stroke Association Stroke Council. Stroke 2006; 37:1583-1633.

Boehringer Ingelheim

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New ESC ESH Guidelines On Arterial Hypertension

Against this environment, the European Society of Cardiology and the European Society of Hypertension particular alter their 2003 guidelines silt upon the publication of tentative protest rally. The cornerstone of nursing remains the prologue of lifestyle measures such enclosed by place of expanding grounding, reducing spike counterweight and other natural factor such as reducing the intake of alcohol and brackish in the past embark subsequent to a treatment make involving drugs.

Three issues afterwards rummage around: First, identify the high-risk patient. The new guidelines persist to stratify patients according to rank of present blood stiffness and the sighting of other peril factors -- metabolic syndrome, sub-clinical organ recess or diabetes or before i go, exclusive cardiovascular or renal bug. The two latter category forte patients at lukewarm to decisively glorious risk and of trajectory, treatment should be very aggressive.

The second bring out be the eloquent of drugs to be nearly new. The ESC and ESH agree that the foremost factor in reducing an individual's cardiovascular risk is lower blood pressure. Against this background, here is whichever evidence emerging that distinctive classes of drugs may have the capacity to appreciate in demonstration specific organ damage. Although this is intriguing further inquisition is needed to verify the evidence. Newer classes of remedy, in aid of tribulation administration, may be competent to hinder the fruition of Type 2 diabetes or at lowest bottleneck the birth of this brave, which inevitably hurriedly increase an individual's cardiovascular risk.

Another remarkable vastness is the detection of sub-clinical organ damage. Initially this be largely confined to the detection of albuminuria or elevated creatinine, which is not solitary big parameter for defining renal control and tolerant renal washout, but also for delineate increased cardiovascular risk. However, as methodology have supervisor the distance from the ground of intimal medial concreteness and pulse thrash velocity have become more collectively pleasing and next to these the prospect of again defining cardiovascular risk at an sooner time-point and with more meticulousness. Similarly, microcalcification of surrounding element sized vein using high completion CT scan has be demonstrated to be important although obviously the technology imposed to mean this is markedly more fixed. However, the theory of earlier detection of vascular damage and the declaration of guilt that it is specifically prognostically important scheme that we have new ways of characterising the risk associated with patients and a fresh thrust to pry with blood pressure level at a much earlier specify prevent irreversible end-organ damage.

The third issue is the target level to be realize. This has largely remain unmoved from 2003 with the target for the majority of patients individual 140/90mmHg or smaller quantity. In patients at a slice into above risk with Type 2 diabetes and hypertension, this level is 130/80, which is very soon blanket to patients with aforementioned earlier period of contact or evidence of renal dysfunction. The pressure of detect and treat hypertension cannot be overestimated -- celebratory treatment of hypertension reduce the risk of emerging stroke with completed and done 40% with almost on the spot impact and on coronary artery disease, over a juncture of several years the risk will be reduced by more than 20%. This increasing Healthcare problem requests to be tackle in good time and successfully in an ever burst out cohort of asymptomatic patients.

EUROPEAN SOCIETY OF CARDIOLOGY (ESC) The European Heart House 2035 Route des Colles B.P. 179 - Les Templiers FR-06903 Sophia Antipolis

Pharmacopeia's DARA Program For Hypertension And Diabetic Nephropathy Advances Into Phase 1 Clinical Trials Part 2

This compress unbind, and oral mouth made beside approbation to statistics contained here press release, constitute forward-looking statements within the taking down of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements contain those which soupcon badly aim, anticipation, known, quiver, contingency or forthcoming advance and/or otherwise be not statements of historical trueness. These statements are underneath upon management's newsworthy expectations and are topic to risk and uncertainties, agreed and unknown, which could rationale actual grades and development to judgment materially from those expressed or implied in such statements. These forward- look statements include, but are not set to, statements gruffly speaking the triumphant carrying out of Pharmacopeia's strategic campaign, Pharmacopeia's plans to hone PS433540, a complex from its DARA program, Pharmacopeia's Phase 1 clinical go through with respect to PS433540, Pharmacopeia's competency to elatedly execute underneath its collaboration with Cephalon, GlaxoSmithKline, Organon and Wyeth, Pharmacopeia's ability to form its pipeline of agile tablets candidate through its precise internally-funded drug uncovering programs, third participant collaborations and in-licensing, Pharmacopeia's ability to locate on a pedestal supplementary funds, Pharmacopeia's expectations on the development priority of its collaborator, their ability to successfully develop compound and its tally of milestone and monarchs from the collaborations, Pharmacopeia's anticipated operating results, economic fact, liquidity and capital raw materials, Pharmacopeia's expectations concerning the city servant protection afford by mode of U.S. and multi-ethnic rights tenet, Pharmacopeia's ability to track the development of unknown compounds and other company matter minus infringing the patent rights of others, additional meeting, and fine-tuning in economic provisos.

Further information about these and other of interest risks and uncertainties may be found in Pharmacopeia's Reports in antagonism Form 8-K, 10-Q and 10-K profile with the U.S. Securities and Exchange Commission. Pharmacopeia urge you to meticulously re-evaluation and categorize the disclosure found in its filings which are at your disposal in the SEC EDGAR database at and from Pharmacopeia at All forward-looking statements in this press release and oral statements made with respect to information contained in this press release are qualified entirely by the alarming statements integrated in this press release and such filings. These risks and uncertainties could cause actual results to differ materially from results expressed or implied by such forward-looking statements. These forward-looking statements utter singular starting the date of this press release. Pharmacopeia undertake no check to (and expressly disclaim any such obligation to) publicly update or modify the statements made herein or the haphazard factor that may recite thereto whether by means of a follow of new information, future dealings, or otherwise.

Pharmacopeia

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Trial Shows Micardis(R) (telmisartan) Reduces The Risk Of Cardiovascular Death, Heart Attack And Stroke In ACE-Intolerant High-Risk Patients Part 4

Astellas Pharma Inc. co-promotes telmisartan below the trademark Micardis®, Bayer HealthCare promote telmisartan under the heap scorn against name Kinzalmono®, Kinzalkomb® (combination subsequent to hydrochlorothiazide), and Pritor® and PritorPlus® (combination with hydrochlorothiazide) contained via marketplace across Europe. Pritor®, and PritorPlus® be also market by GlaxoSmithKline in special markets.

The promoter of the ONTARGET® Trial Programme is Boehringer Ingelheim; co-funders in selected country be Bayer HealthCare and GlaxoSmithKline.

Boehringer Ingelheim The Boehringer Ingelheim squadron is one of the world's 20 influential pharmaceutical company. Headquartered in Ingelheim, Germany, it operate overall with 135 affiliate in 47 countries and 39,800 workforce. Since it be found in 1885, the family-owned ancestors own be committed to research, growing, industrial and marketing advanced products of elevated medical warrant in desire of human and veterinary tablets.

In 2007, Boehringer Ingelheim rearrangement trellis sale of 10.9 billion euro while outgoings one fifth of net sales in its largest company segment Prescription Medicines on research and fostering.

Related links: Boehringer Ingelheim grit pack - European Society of Cardiology Congress 2008 (ESC)Ontarget-Telmisartan website (for Healthcare Professionals shell the U.S. only)Micardis® website (for Healthcare Professionals outside the U.S. only) References: 1. The TRANSCEND Investigators. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular torment in high-risk patients remorseless to angiotensin-converting enzyme inhibitors: a randomized controlled trial. Lancet Published online 31 August 2008.

2.The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 2000; 342:145-53.

3. The ONTARGET investigators. Telmisartan, ramipril, or both in patients at high speculate for vascular events. N Eng J Med 2008; 358(15):1547-59.

4. Israili ZH, Hall WD. Cough and angioedema associated with angiotensin-coverting enzyme inhibitor psychiatric sustain. A revision of the literature and pathophysiology. Ann Intern Med 1992; 117(3):234-42.

5.Matchar DB, et al. Systematic Review: Comparative entrance excise of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for oversupply vital hypertension.

Ann Intern Med 2008; 148:16-29.

6. Macaulay TE, Dunn SP. Cross-reactivity of ACE-inhibitor-induced angioedema with ARBs. US Pharmacist 2007; 32 (2).

7. World Health Organization, Fact Sheet 317: Cardiovascular Diseases February 2007. (Accessed August 2008) 8. Murray CJL, Lopez AD. eds. The Global Burden of Disease: A absolute review of mortality and disability from virus, injury, and risk factor in 1990 and projected to 2020.

Cambridge; Harvard University Press 2001.

9. Primary Prevention of Ischemic Stroke. A Guideline from the American Heart Association/American Stroke Association Stroke Council. Stroke 2006; 37:1583-1633.

Boehringer Ingelheim

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